pS347-mS1P5 (phospho-mouse-Sphingosine 1-Phosphate Receptor 5 Antibody)

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Agonist-induced Serine347 phosphorylation of the mouse Sphingosine 1-Phosphate Receptor 5

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Order number: 7TM0279D
Content: 100 µl
Host: Rabbit

Serine347 (S347) is major phosphorylation site of the mouse Sphingosine 1-Phosphate Receptor 5... more

Serine347 (S347) is major phosphorylation site of the mouse Sphingosine 1-Phosphate Receptor 5 (S1P5). The pS347-mS1P5 antibody detects phosphorylation in response to agonists. S347 phosphorylation is likely to be involved in efficient ligand sequestration by mS1P5.

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Alternative Names Edg8, endothelial differentiation G protein-coupled... more

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Alternative Names	Edg8, endothelial differentiation G protein-coupled receptor 8, NRG-1
IUPHAR Target ID	279
UniProt ID	Q91X56
Western Blot (WB)	1:1000
Species Reactivity	Mouse
Host / Isotype	Rabbit / IgG
Class	Polyclonal
Immunogen	A synthetic phosphopeptide derived from mouse S1P5 around the phosphorylation site of Ser347.
Form	Liquid
Purification	Antigen affinity chromatography
Storage buffer	Dulbecco's PBS, pH 7.4, with 150 mM NaCl, 0.02% sodium azide
Storage conditions	short-term 4°C, long-term -20°C

Figure 1. Agonist-induced Serine347 phosphorylation of the mouse Sphingosine 1-Phosphate... more

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Figure 1. Agonist-induced Serine347 phosphorylation of the mouse Sphingosine 1-Phosphate Receptor 5. Upper panel, HEK293 cells stably expressing the mouse S1P5-Receptor (mS1P5) were either not exposed or exposed to 1 µM of S1P5-Receptor agonists S1P for 30 minutes. Cells were lysed and immunoblotted with the anti-pS347-mS1P5 antibody (7TM00279D) at a dilution of 1:1000. Lower panel, blot was stripped and reprobed with the phosphorylation-independent anti-mS1P5 antibody (7TM0279MN) to confirm equal loading of the gel.

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