Calcitonin Receptor Antibodies

The calcitonin receptor family comprises a group of receptors for the calcitonin/CGRP family of peptides. The calcitonin (CT), amylin (AMY), calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) receptors are generated by the genes CALCR (which codes for the CT receptor) and CALCRL (which codes for the calcitonin receptor-like receptor, CLR). Whilst the receptor for calcitonin is a conventional class B GPCR, the receptors for CGRP, AM and amylin require additional proteins, called the receptor activity modifying proteins (RAMPs). There are three RAMPs in mammals; they interact with the CT receptor to convert it to receptors for amylin. For CGRP and AM, the related calcitonin receptor-like receptor interacts with RAMP1 to give a CGRP receptor and RAMP2 or 3 to give AM receptors. Calcitonin receptor-like receptor by itself will bind no known endogenous ligand. The endogenous agonists are the peptides calcitonin, α-CGRP, β-CGRP, amylin, adrenomedullin and adrenomedullin 2/intermedin. The calcitonin peptide family is involved in numerous physiological and pharmacological activities. There are several approved drugs that target this receptor family, such as pramlintide, erenumab, and the "gepant" class of CGRP receptor antagonists.