GPR34 Receptor Antibodies

GPR34 (G Protein-Coupled Receptor 34) is an orphan GPCR that has been proposed to respond to lysophosphatidylserine (LysoPS), a lipid signaling molecule involved in immune regulation and inflammation. While the receptor-ligand interaction is still under investigation, GPR34 is thought to influence immune cell function and inflammatory signaling pathways. GPR34 is expressed in various tissues, with notable levels in immune cells such as microglia, macrophages, and B lymphocytes, as well as in the central nervous system, spleen, and gastrointestinal tract. It is also found in some cancer types, including gastric and colorectal cancers. GPR34 is considered a potential pharmacological target, particularly in the fields of immunology, inflammation, and oncology. Its role in immune cell signaling and tumor progression has led to growing interest in its therapeutic potential, although no selective modulators are currently available. For more information on GPR34 pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

Alexander SP, Battey J, Benson HE, Benya RV, Bonner TI, Davenport AP, Dhanachandra Singh K, Eguchi S, Harmar A, Holliday N, Jensen RT, Karnik S, Kostenis E, Liew WC, Monaghan AE, Mpamhanga C, Neubig R, Pawson AJ, Pin JP, Sharman JL, Spedding M, Spindel E, Stoddart L, Storjohann L, Thomas WG, Tirupula K, Vanderheyden P. Class A Orphans in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F16/2023.1.