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pS338/pS342-AT1 (phospho-Angiotensin Receptor 1... Serine338/Serine342 (S338/S342) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS338/pS342-AT1 antibody detects phosphorylation in response to agonists. S338/S342 phosphorylation is likely to be involved in...
375.00 € *
NEW
pS326/pS328-AT1 (phospho-Angiotensin Receptor 1... Serine326/Serine328 (S326/S328) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS326/pS328-AT1 antibody detects phosphorylation in response to agonists. S326/S328 phosphorylation is likely to be involved in...
375.00 € *
NEW
pS348/pT349-AT1 (phospho-Angiotensin Receptor 1... Serine348/Threonine349 (S348/T349) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS348/pT349-AT1 antibody detects phosphorylation in response to agonists. S348/T349 phosphorylation is likely to be involved in...
375.00 € *
NEW
pS331/pT332-AT1 (phospho-Angiotensin Receptor 1... Serine331/Threonine332 (S331/T332) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS331/pT332-AT1 antibody detects phosphorylation in response to agonists. S331/T332 phosphorylation is likely to be involved in...
375.00 € *
SAMPLE PACK
AT1 Sample Pack (phospho- and... AT1 Sample Pack consisting of all four available phospho- and non-phospho-AT1 Antibodies 7 x 20 µL trial size each.
300.00 € *
NEW
pS346/pS347-AT1 (phospho-Angiotensin Receptor 1... Serine346/Serine347 (S346/S347) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS346/pS347-AT1 antibody detects phosphorylation in response to agonists. S346/S347 phosphorylation is likely to be involved in...
375.00 € *
NEW
pS335/pT336-AT1 (phospho-Angiotensin Receptor 1... Serine335/Threonine336 (S335/T336) is major phosphorylation site of the Angiotensin Receptor 1 (AT1). The pS335/pT336-AT1 antibody detects phosphorylation in response to agonists. S335/T336 phosphorylation is likely to be involved in...
375.00 € *
NEW
AT1 (non-phospho-Angiotensin Receptor 1 Antibody) The non-phospho-AT1 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human Angiotensin Receptor 1 (AT1). It can be used to detect total AT1 receptors in Western blots independent of phosphorylation....
375.00 € *
In humans, the gene encoding the AT1 receptor is located on chromosome 3. The AT1 receptor is ubiquitously expressed, including vascular smooth muscle, liver, kidney, heart, lung, adrenal cortex, pituitary and brain. Agonist binding to the AT1 receptor leads to the recruitment of heterotrimeric Gq/G11 proteins and/or adaptor proteins such as β-arrestin. Classically, the signal transduction mechanisms of the AT1 receptor depend on different effectors including phospholipase C (PLC) and voltage-dependent Ca2+ channels. The β-arrestin2 recruited to the AT1 receptor mediates activation of Ser/Thr kinases such as mitogen-activated protein (MAP) kinase spatially restricted to the cytoplasmic compartment. In rodents, the AT1A and AT1B originate from two closely related, but distinct genes are located on chromosomes 17 and 2, respectively. AT1A and AT1B receptors differ in 19 amino acids, mainly in the C-terminal region. The rodent AT1A and AT1B receptors are pharmacologically indistinguishable and have identical functional properties. Expression of AT1A and AT1B receptor genes are, however, differentially regulated. AT1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal serine326/serine328 (pS326/pS328-AT1), serine331/threonine332 (pS331/pT332-AT1), serine335/threonine336 (pS335/pT336-AT1), serine338/serine342 (pS338/pS342-AT1), serine346/serine347 (pS346/pS347-AT1), and serine348/serine349 (pS348/pS349-AT1. This nomenclature refers to the human AT1 receptor. For more information on AT1 pharmacology please refer to the Recently viewed