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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR161 Receptor in transfected HEK293 cells
GPR161 (GP-non-phospho), G protein-coupled...
The non-phospho-GPR161 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR161. It can be used to detect total GPR161 receptors in Western blots independent of phosphorylation. The GPR161...
375.00 € *
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NEW
Validation of the GPR150 Receptor in transfected HEK293 cells.
GPR150 (non-phospho), G protein-coupled...
The non-phospho-GPR150 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR150. It can be used to detect total GPR150 receptors in Western blots independent of phosphorylation. The GPR150...
375.00 € *
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NEW
Validation of the GPR142 Receptor in transfected HEK293 cells.
GPR142 (non-phospho), G protein-coupled...
The non-phospho-GPR142 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR142. It can be used to detect total GPR142 receptors in Western blots independent of phosphorylation. The GPR142...
375.00 € *
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NEW
Validation of the GPR135 Receptor in transfected HEK293 cells.
GPR135 (non-phospho), G protein-coupled...
The non-phospho-GPR135 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR135. It can be used to detect total GPR135 receptors in Western blots independent of phosphorylation. The GPR135...
375.00 € *
Details
NEW
Validation of the GPR85 Receptor in transfected HEK293 cells.
GPR85 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR85 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR85. It can be used to detect total GPR85 receptors in Western blots independent of phosphorylation. The GPR85 antibody...
375.00 € *
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NEW
Validation of the GPR68 Receptor in transfected HEK293 cells.
GPR68 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR68 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR68. It can be used to detect total GPR68 receptors in Western blots independent of phosphorylation. The GPR68 antibody...
375.00 € *
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NEW
Validation of the GPR45 Receptor in transfected HEK293 cells.
GPR45 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR45 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR45. It can be used to detect total GPR45 receptors in Western blots independent of phosphorylation. The GPR45 antibody...
375.00 € *
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NEW
Validation of the GPR37L1 Receptor in transfected HEK293 cells
GPR37L1 (non-phospho), G protein-coupled...
The non-phospho-GPR37L1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37L1. It can be used to detect total GPR37L1 receptors in Western blots independent of phosphorylation. The GPR37L1...
375.00 € *
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NEW
Validation of the GPR37 Receptor in transfected HEK293 cells
GPR37 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR37 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37. It can be used to detect total GPR37 receptors in Western blots independent of phosphorylation. The GPR37 antibody...
375.00 € *
Details
NEW
Validation of the GPR62 Receptor in transfected HEK293 cells
GPR62 (non-phospho), G protein-coupled...
The non-phospho-GPR62 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR62. It can be used to detect total GPR62 receptors in Western blots independent of phosphorylation. The GPR62 antibody...
375.00 € *
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Serine422/Serine423 phosphorylation of the G-protein coupled Receptor 75
pS422/pS423-GPR75 (phospho-GPR75 Antibody)
Serine422/Serine423 (S422/S423) is a major phosphorylation site of the human GPR75 receptor. The pS422/pS423-GPR75 antibody detects GRK-mediated constitutive phosphorylation as well as PKC-mediated phosphorylation of GPR75 when expressed...
375.00 € *
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Validation of the GPR97/ADGR3G Receptor in transfected HEK293 cells
ADGRG3/GPR97 (non-phospho), Adhesion Receptor...
The non-phospho-ADGRG3/GPR97 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human ADGRG3/GPR97. It can be used to detect total ADGRG3/GPR97 receptors in Western blots independent of phosphorylation....
375.00 € *
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NEW
Validation of the GPR161 Receptor in transfected HEK293 cells
GPR161 (non-phospho), G protein-coupled...
The non-phospho-GPR161 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR161. It can be used to detect total GPR161 receptors in Western blots independent of phosphorylation. The GPR161...
375.00 € *
Details
NEW
Agonist-induced Serine300/Serine303 phosphorylation of GPR35 Receptor.
pS300/pS303-hGPR35 (phospho-human GPR35 Antibody)
Serine300/Serine303 (S300/S303) is a major phosphorylation site of the human GPR35 receptor. The pS300/pS303-hGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S300/S303 phosphorylation is a key regulator of...
375.00 € *
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Agonist-induced Serine298/Serine301 phosphorylation of mouse GPR35 Receptor
pS298/pS301-mGPR35 (phospho-mouse GPR35 Antibody)
Serine298/Serine301 (S298/S301) is a major phosphorylation site of the mouse GPR35 receptor. The pS298/pS301-mGPR35 antibody detects phosphorylation in response to high-efficacy agonists. S298/S301 phosphorylation is a key regulator of...
375.00 € *
Details
NEW
Validation of the GPR75 Receptor in transfected HEK293 cells
GPR75 (GP-non-phospho), G protein-coupled...
The non-phospho-GPR75 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR75. It can be used to detect total GPR75 receptors in Western blots independent of phosphorylation. The GPR75 antibody...
375.00 € *
Details
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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