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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR75 Receptor in transfected HEK293 cells
GPR75 (GP-non-phospho), G protein-coupled...
The non-phospho-GPR75 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR75. It can be used to detect total GPR75 receptors in Western blots independent of phosphorylation. The GPR75 antibody...
375.00 € *
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GPR75 (GP-IHC-Grade), G protein-coupled Receptor 75 Antibody, Guinea Pig
GPR75 (GP-IHC-Grade), G protein-coupled...
The non-phospho-GPR75 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR75. It can be used to detect total GPR75 receptors in Western blots independent of phosphorylation. The GPR75 antibody...
375.00 € *
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Validation of the GPR37L1 Receptor in transfected HEK293 cells
GPR37L1 (non-phospho), G protein-coupled...
The non-phospho-GPR37L1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37L1. It can be used to detect total GPR37L1 receptors in Western blots independent of phosphorylation. The GPR37L1...
375.00 € *
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GPR37L1 (IHC-Grade), G protein-coupled Receptor 37L1 Antibody
GPR37L1 (IHC-Grade), G protein-coupled Receptor...
The non-phospho-GPR37L1 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37L1. It can be used to detect total GPR37L1 receptors in Western blots independent of phosphorylation. The GPR37L1...
375.00 € *
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Validation of the GPR68 Receptor in transfected HEK293 cells.
GPR68 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR68 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR68. It can be used to detect total GPR68 receptors in Western blots independent of phosphorylation. The GPR68 antibody...
375.00 € *
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GPR68 (IHC-Grade), G protein-coupled Receptor 68 Antibody
GPR68 (IHC-Grade), G protein-coupled Receptor...
The non-phospho-GPR68 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR68. It can be used to detect total GPR68 receptors in Western blots independent of phosphorylation. The GPR68 antibody...
375.00 € *
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NEW
Validation of the GPR161 Receptor in transfected HEK293 cells
GPR161 (non-phospho), G protein-coupled...
The non-phospho-GPR161 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR161. It can be used to detect total GPR161 receptors in Western blots independent of phosphorylation. The GPR161...
375.00 € *
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Agonist-induced Serine323/Serine324 phosphorylation of the GPR139 Receptor
pS323/pS324-GPR139 (phospho-GPR139 Antibody)
Serine323/Serine324 (S323/S324) is major phosphorylation site of the GPR139 Receptor (GPR139). The pS323/pS324-GPR139 antibody detects phosphorylation in response to agonists. S323/S324 phosphorylation is likely to be involved in...
375.00 € *
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Agonist-induced Threonine315 phosphorylation of the GPR139 Receptor
pT315-GPR139 (phospho-GPR139 Antibody)
Threonine315 (T315) is major phosphorylation site of the GPR139 Receptor (GPR139). The pT315-GPR139 antibody detects phosphorylation in response to agonists. T315 phosphorylation is likely to be involved in efficient ligand sequestration.
375.00 € *
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Agonist-induced Threonine377 phosphorylation of GPR88-Receptor
pT377-GPR88 (phospho-GPR88 Antibody)
Threonine377 (T377) is a major phosphorylation site of the human GPR88 receptor. The pT377-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. T377 phosphorylation is a key regulator of human GPR88...
375.00 € *
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Agonist-induced Serine346/Serine349 phosphorylation of GPR88-Receptor
pS346/pS349-GPR88 (phospho-GPR88 Antibody)
Serine346/Serine349 (S346/S349) is a major phosphorylation site of the human GPR88 receptor. The pS346/pS349-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. S346/S349 phosphorylation is a key regulator of...
375.00 € *
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Agonist-induced Serine371 phosphorylation of GPR88-Receptor.
pS371-GPR88 (phospho-GPR88 Antibody)
Serine371 (S371) is a major phosphorylation site of the human GPR88 receptor. The pS371-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. S371 phosphorylation is a key regulator of human GPR88 desensitization,...
375.00 € *
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Agonist-induced Threonine365/Serine371/Threonine377 phosphorylation of GPR88-Receptor
pT365/pS371/pT377-GPR88 (phospho-GPR88 Antibody)
Threonine365/Serine371/Threonine377 (T365/S371/T377) is a major phosphorylation site of the human GPR88 receptor. The pT365/pS371/pT377-GPR88 antibody detects phosphorylation in response to high-efficacy agonists. T365/S371/T377...
375.00 € *
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Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (GP-non-phospho), G Protein-coupled...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
375.00 € *
Details
NEW
Validation of the GPR37 Receptor in transfected HEK293 cells
GPR37 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR37 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR37. It can be used to detect total GPR37 receptors in Western blots independent of phosphorylation. The GPR37 antibody...
375.00 € *
Details
NEW
Validation of the GPR45 Receptor in transfected HEK293 cells.
GPR45 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR45 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR45. It can be used to detect total GPR45 receptors in Western blots independent of phosphorylation. The GPR45 antibody...
375.00 € *
Details
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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