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Orphan Receptor Antibodies

The sequencing of the human genome has allowed NC-IUPHAR to catalog all of the human gene sequences potentially encoding GPCRs, excluding sensory receptors. In addition to established transmitter systems, the classification in the Guide to PHARMACOLOGY also includes ‘orphan’ GPCRs where the endogenous ligand(s) is not known. Considerable progress has been made in screening artificially expressed receptors to identify the cognate endogenous ligand.

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Validation of the GPR18 Receptor in transfected HEK293 cells.
GPR18 (non-phospho), G protein-coupled...
The non-phospho-GPR18 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR18. It can be used to detect total GPR18 receptors in Western blots independent of phosphorylation. The GPR18 antibody...
375.00 € *
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Immunohistochemical identification of Serine351/Threonine356 phosphorylation of G-protein coupled Receptor 17 in oligodendrocytes
pS351/pT356-GPR17 (IHC-Grade phospho-GPR17...
Serine351/Threonine356 (S351/T356) is a major phosphorylation site of the human GPR17 receptor. The pS351/pT356-GPR17 antibody detects phosphorylation in response to high-efficacy agonists. S351/T356 phosphorylation is a key regulator of...
550.00 € *
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NEW
Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (GP-non-phospho), G Protein-coupled...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
375.00 € *
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NEW
Indentification of GPR183 Receptor in mouse tissues
GPR183 (GP-non-phospho), Oxysterol Receptor...
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
375.00 € *
Details
NEW
Validation of the GPR55 Receptor in transfected HEK293 cells
GPR55 (non-phospho), G protein-coupled...
The non-phospho-GPR55 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR55. It can be used to detect total GPR55 receptors in Western blots independent of phosphorylation. The GPR55 antibody...
375.00 € *
Details
NEW
Validation of the GPR146 Receptor in transfected HEK293 cells
GPR146 (non-phospho), G protein-coupled...
The non-phospho-GPR146 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR146. It can be used to detect total GPR146 receptors in Western blots independent of phosphorylation. The GPR146...
375.00 € *
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NEW
Validation of the GPR119 Receptor in transfected HEK293 cells
GPR119 (non-phospho), G protein-coupled...
The non-phospho-GPR119 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR119. It can be used to detect total GPR119 receptors in Western blots independent of phosphorylation. The GPR119...
375.00 € *
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Immunohistochemical identification of GPR183 Receptor in human spleen
GPR183 (IHC-grade), Oxysterol Receptor Antibody
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
375.00 € *
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NEW
Validation of the MRGPRX2 Receptor in transfected HEK293 cells
MRGPRX2 (non-phospho), MRGPRX2 Mas-related...
The non-phospho-MRGPRX2 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human MRGPRX2. It can be used to detect total MRGPRX2 receptors in Western blots independent of phosphorylation. The MRGPRX2...
375.00 € *
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NEW
Validation of the GPR82 Receptor in transfected HEK293 cells
GPR82 (non-phospho), G protein-coupled...
The non-phospho-GPR82 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR82. It can be used to detect total GPR82 receptors in Western blots independent of phosphorylation. The GPR82 antibody...
375.00 € *
Details
NEW
Validation of the GPR65 Receptor in transfected HEK293 cells
GPR65 (non-phospho), G protein-coupled...
The non-phospho-GPR65 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR65. It can be used to detect total GPR65 receptors in Western blots independent of phosphorylation. The GPR65 antibody...
375.00 € *
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NEW
Validation of the GPR61 Receptor in transfected HEK293 cells
GPR61 (non-phospho), G protein-coupled...
The non-phospho-GPR61 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR61. It can be used to detect total GPR61 receptors in Western blots independent of phosphorylation. The GPR61 antibody...
375.00 € *
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NEW
Validation of the GPR3 Receptor in transfected HEK293 cells
GPR3 (non-phospho), G protein-coupled Receptor...
The non-phospho-GPR3 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR3. It can be used to detect total GPR3 receptors in Western blots independent of phosphorylation. The GPR3 antibody can...
375.00 € *
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pT427/pS429-GPR75 (IHC-grade phospho-GPR75 Antibody)
pT427/pS429-GPR75 (IHC-grade phospho-GPR75...
Threonine427/Serine429 (T427/S429) is a major phosphorylation site of the human GPR75 receptor. The pT427/pS429-GPR75 antibody detects GRK-mediated constitutive phosphorylation of GPR75 when expressed in HEK293 cells.
550.00 € *
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NEW
Validation of the G Protein-coupled Receptor 17 in transfected HEK293 cells
GPR17 (non-phospho), G Protein-coupled Receptor...
The non-phospho-GPR17 receptor antibody is directed against the distal part of the carboxyl-terminal tail of human GPR17. It can be used to detect total GPR17 receptors in Western blots independent of phosphorylation. The...
375.00 € *
Details
NEW
Validation of the GPR183 Receptor in transfected HEK293 cells
GPR183 (non-phospho), Oxysterol Receptor Antibody
The non-phospho-GPR183 receptor antibody is directed against the distal end of the carboxyl-terminal tail of human GPR183. It also detects GPR183 in cultured cells and tissue sections by immunohistochemistry. It can be used to detect...
375.00 € *
Details
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For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

For more information on orphan receptor pharmacology please refer to the  IUPHAR  database. For further reading refer to: Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE,... read more »
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Orphan Receptor Antibodies

For more information on orphan receptor pharmacology please refer to the IUPHAR database. For further reading refer to:

Davenport AP, Alexander SP, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga CP, Bonner TI, Neubig RR, Pin JP, Spedding M, Harmar AJ. International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands. Pharmacol Rev. 2013 May 17;65(3):967-86. doi: 10.1124/pr.112.007179. PMID: 23686350; PMCID: PMC3698937.

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